Estimate Stoessel Classification for Reaction Hazards

The Stoessel criticality class is well-known among the Process Safety community to systematically assess the thermal risks associated to the scale up of chemical processes. Such a classification can be obtained after the full characterization of the chemical process by calorimetric techniques (e.g. RC1 and DSC), unfortunately, this usually requires dedicated experiments at the Process Safety lab and involves lengthy calibrations to characterize the thermal behavior of the system (i.e. heat capacity and heat transfer). Therefore, having a simplified methodology would avoid compromising the agility required at early stages of a research project.

In this webinar we will share a methodology to effectively estimate the Stoessel classification of any process by just using a small-scale experiment, recorded in an automated synthesis reactor, in combination with the previous calorimetric characterization of the typical solvents used in pharmaceutical development.