Experience EVA Karl Fischer Titrators—a comprehensive product family spanning volumetric to coulometric solutions, where advanced engineering meets sophisticated software to enhance precision and efficiency. Equipped with the Fast Forecasting Amperometric (FFA™) Algorithm and dSens M143 sensor, these titrators offer swift, accurate water content determination. The Swiss-made modular design caters to diverse lab needs, boosting throughput and maintaining reliable results.
High Efficiency: Rapid water-content titrations driven by the FFA™ control algorithm boost throughput without sacrificing accuracy.
Versatility: Modular design scales from stand-alone benchtop setups to fully automated racks, adapting to any lab footprint.
Seamless Workflows: OneClick™ touchscreen and LabX™ software unite method setup, data capture, and CFR-ready reporting.
Optimal Safety: Closed-loop solvent exchange and spill-proof cell design protect users and benches
Regulatory Compliance: Built-in audit trails and e-signatures support 21 CFR Part 11 and EU Annex 11 requirements.
Sustainable Practices: Paperless documentation, ethanol-based reagents, and low-solvent protocols cut chemical use and waste.
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Understand How The FFA™ Algorithm Works
This video explores the Fast Forecasting Amperometric (FFA™) Algorithm in EVA Karl Fischer Titrators. Learn how this advanced feature dynamically adjusts reagent concentrations for faster, more accurate titrations, significantly enhancing laboratory efficiency and precision in water content determination.
Fast Forecasting Amperometric (FFA™) Algorithm: Optimizes reagent concentration with advanced control technology, accelerating reaction rates for rapid, precise water content determination.
Rapid-Response Digital Sensor: Equipped with the interference-free dSens M143 sensor, delivering immediate and accurate data capture for reliable results.
Precision Titrant Addition: V1 and V3 Utilizes a high-resolution dDrive unit with 120,000 steps, providing precise, dispensing that automatically adjusts to sample demands.
Swiss Versatility
Swiss craftsmanship: Known for their reliability and quality, these titrators are designed to meet the rigorous demands of modern labs.
Plug-and-Measure: Modules snap in instantly, letting you reconfigure burettes, sensors, and cells as workflows evolve.
Versatile applications: Supports diverse industry requirements with extensive accessory options, ensuring compatibility across various sample types.
Seamless Workflow
Intuitive OneClick™ interface: Simplifies lab operations, enhancing usability for all skill levels.
Automated workflow: Instantly transfers sample weight data and titrant information, reducing transcription errors. Convenient features like automatic sample detection and method start enhance efficiency overall.
Seamless LabX™ integration: Connects with LIMS, ELN, MES, and CDS to reduce IT overhead and improve efficiency.
InMotion Autosampler: Enables unattended workflows from low to high throughput, offering optional oven extraction for challenging samples and minimizing manual intervention, compatible with V1/V3 and C1/C3 titrators.
Regulatory Compliance and Traceability
EVA Karl Fischer Titrators integrate effortlessly with LabX™, enhancing data management and supporting Regulatory Compliance with standards like 21 CFR Part 11 and EU Annex 11. Key features include centralized user management, electronic signatures, and comprehensive audit trails. Adherence to ALCOA++ principles boosts data integrity while streamlining validation and maintenance.
Optimal Safety
Advanced solvent management: Automates chemical dispensing to reduce exposure and leaks, ensuring a safer, cleaner lab environment.
Remote operation capabilities: Features a detachable touchscreen with a 2.5-meter cable and OneClick™ interface for safe, remote operation, reducing risks with hazardous substances.
Safety-driven design: Incorporates an enclosed system to prevent spills and minimize chemical handling, protecting users and maintaining consistent titration accuracy.
Sustainable Practices
EVA Karl Fischer Titrators, paired with LabX™ software, foster sustainable laboratory operations through paperless workflows and reduced resource consumption. By streamlining processes, enhancing reproducibility, and minimizing errors, they enable eco-friendly lab practices. Their design minimizes solvent usage, especially in ultra-low water content determinations, reducing both costs and environmental impact—offering fast, accurate titrations for modern, environmentally conscious laboratories.
Methods
Volumetric or Coulometric? Match Your Method to Your Needs
Choosing between volumetric and coulometric titration ensures the right fit for your lab. Volumetric suits high water content in food, pharma, and chemicals, while coulometric excels in ultra-low detection for petrochemicals, plastics, and electronics. EVA Karl Fischer Titrators adapt to your sample and workflow needs.
Instruments
Volumetric Karl Fischer Titrators
Covering water content ranges of 100 ppm to 100%, these volumetric instruments offer rapid, consistent measurements. Their adaptable design suits multiple sample types and high-throughput labs, combining Swiss-made precision with advanced control algorithms for efficiency and reliability.
EVA Karl Fischer Titrator V1
Precision simplified: The EVA V1 Titrator excels in determining water content in soluble samples with speed and accuracy. Perfect for routine testing, it combines simplicity with efficiency.
Top performance: Measurment for simple liquids and soluble, ensuring fast and accurate water content determination.
Ease of use: Designed with user-friendliness in mind, simplifyingroutine tests and making complex setup more manageable.
Optimal choice: ideal for labs aiming to boost productivity and operational excellence.
Streamlined operations: Boost throughput with an instrument built for high-volume testing and optional walk-away runs via the 5-position InMotion KF Six autosampler.
EVA Karl Fischer Titrator V3
Advanced versatility: The EVA V3 Titrator simplifies water content determination across diverse sample types. It supports homogenizer attachment, external sample extraction, and integrates with the InMotion KF autosampler for high-throughput automation—ideal for tackling even the most challenging applications.
Wide Sample Compatibility: From semi-solids to challenging matrices, the V3 handles them all with speed and precision—featuring a homogenizer attachment for consistent, uniform solutions.
External Extraction: Isolate water from non-dissolving samples, protecting the main unit and effectively managing reactive or corrosive materials.
High-Throughput Automation: Integrate with the InMotion KF autosampler to process multiple samples efficiently, boosting overall lab productivity.
Coulometric Karl Fischer Titrators
For ultra-low water content (1 ppm – 5%), these coulometric systems pair optimized reagent use with advanced algorithms, delivering rapid analyses without sacrificing trace-level sensitivity for batteries, electronics, petrochemicals, and specialty chemicals.
EVA Karl Fischer Titrator C1
Trace-level precision simplified: EVA C1 Titrator delivers rapid yet accurate analyses. Optimized reagent usage and advanced algorithms ensure speed doesn’t compromise trace-level sensitivity, making it indispensable in sectors like batteries, electronics, petrochemicals, and specialty chemicals.
Optional Automation: Works with the compact 5-position InMotion KF Six autosampler for unattended trace-level sequences runs and extra walk-away time.
EVA Karl Fischer Titrator C3
Automated trace-level versatility: Building on the strengths of the C1, the EVA C3 Titrator seamlessly integrates with the InMotion KF autosampler for high-throughput workflows. Designed to handle complex matrices and larger sample volumes, it delivers precise, efficient results in demanding lab environments.
Advanced Sample Handling: External extraction and blank management adapt to specialized solvents and challenging matrices.
Workflow Optimization: Intelligent algorithms ensure efficient reagent usage and maintain fast and precise results, even with complex or high-volume workflows.
Accessories
Boost Lab Capabilities with Advanced Accessories
Experience Wide-Ranging Analytical Flexibility for Diverse Applications
Elevate your analysis with our specialized accessories, including thermostable vessels, homogenizer adapters, and drying ovens. These tools simplify the handling of challenging samples, ensuring precise results. Customize your Karl Fischer process with options like varied burette sizes and extended terminal cables for greater convenience and flexibility.
Use a thermovessel with the EVA Karl Fischer Titrator to measure water content in antibiotics accurately. The controlled temperature increase facilitates the effective release of water from solid pharmaceuticals, ensuring accurate and reliable analysis critical for quality assurance.
To accurately analyze water content in gummy bears, utilize the EVA V3 Titrator equipped with a homogenizer for fast and easy sample dispersion. This setup is ideal for efficiently determining water content in high-moisture food samples like gummy bears, ensuring precise and reliable analysis crucial for optimizing texture and shelf life.
Acetone, a widely used organic solvent in many different market segments, reacts with methanol present in the KF reagents. As a result, additional water is produced, leading to higher water contents. Reliable and fast water content determination in acetone is achieved with the EVA Karl Fischer Titrators by using specific methanol-free reagents to suppress the side reaction.
Performing General System Suitability Test (GSST) with Direct Injection Using EVA Karl Fischer Titrators
Prepare your sample according to the GSST protocol and utilize the direct injection feature of the EVA Karl Fischer Titrators for efficient analysis. This method enhances the precision and speed of water content determination across various samples, maintaining adherence to rigorous analytical standards.
To obtain accurate results, it's crucial to determine the current concentration of the KF titrant precisely before beginning the sample titration. Sodium tartrate serves as an excellent reference material for this purpose. Be sure to weigh and dissolve it in the KF solvent with utmost precision. This crucial step will allow you to achieve a precise titrant concentration with your EVA Karl Fischer Titrator, ensuring the reliability of subsequent sample analyses.
Insoluble solids release their water slowly into the KF solvent, leading to prolonged analysis times. External extraction shifts the time-consuming water extraction step to an external vessel. This ensures the EVA Karl Fischer Titrator isn't blocked for minutes or hours while the solvent extracts the water. Once the water content is extracted, it's transferred to the titrator for precise and thorough determination, meeting the specific needs of solid samples like tea leaves.
Understanding the water content in food is essential for determining factors like product shelf life during storage and transport, as well as its edible quality. Accurately assessing water content is thus important in production processes and quality control. Since honey is difficult to dissolve in the KF solvent, formamide is used as an auxiliary solvent to ensure complete dissolution. This allows the water to be fully released and analyzed with the EVA Karl Fischer Titrator, leading to precise quantification and improved accuracy through proper sample preparation.
Measuring Water Content in Edible Oils with EVA Karl Fischer Titrators
Increase the solubility of your edible oil samples in the Karl Fischer solvent using a mixture of chloroform and decanol. Analyze them by direct addition into the EVA Karl Fischer Titrator for precise and reliable quantification of water content, essential for assessing the quality and shelf-life of edible oils.
EVA Karl Fischer Titrators support ethanol-based reagents, providing an eco-friendlier alternative to the conventional methanol. Traditionally, ethanol’s lower reactivity led to longer titrations and reduced accuracy. Thanks to advancements in measuring algorithms and modern reagent formulations, these issues have been resolved. Labs can perform accurate titrations with these safer and greener ethanol-based reagents enhancing sustainability without sacrificing speed and precision.
The European Pharmacopoeia's Chapter 2.5.12 outlines a suitability test for the volumetric Karl Fischer titration technique. Verify the accuracy of water content determination for a given combination of sample, titrant, and solvent. Our application note offers detailed, step-by-step guidance on executing the suitability test using EVA Karl Fischer titrator.
Coulometric Applications
Isolating Trace Water in Mineral & Crude Oils with EVA Karl Fischer Titrators
Heavy petroleum products can trap water at ultra-low levels, complicating direct titration. By pairing EVA C3 with external extraction techniques, labs effectively isolate and quantify trace water. The automation features of the C3 further streamline multiple-sample workflows—ideal for high-throughput environments in the petrochemical sector.
Determining Water Content in Plastics & Polymers Using an Oven with EVA Karl Fischer Titrators
Plastic pellets and polymers are difficult to dissolve in KF solvents, requiring different techniques for water release. The EVA C3 Titrator, combined with the InMotion KF Oven autosampler, efficiently heats these samples to extract water. This setup minimizes operator intervention while maintaining the accuracy critical for R&D and quality control in polymer applications.
Comprehensive Battery & Electronics Testing with EVA Karl Fischer Titrators
For battery materials—including active materials, cathodes, anodes, and electrolytes—the EVA C3 Titrator paired with the InMotion KF Oven provides a unified testing platform. Heat solid components to release water or directly inject electrolyte—all within a single automated system. This ensures consistent ppm-level precision, crucial in battery and electronics manufacturing.
Learn How to Use a Karl Fischer Titrator
This video is designed to guide you through the entire process of setting up and maintaining your new EVA titrator. From the initial installation to routine self-maintenance, we'll walk you through each step so you can get the most out of your investment.
Gain in-depth knowledge about the weighing techniques used in KF titrations. Discover practical and...
FAQs
FAQs
What is an EVA Volumetric KF titrator?
The EVA Volumetric KF Titrator is a device that uses Karl Fischer titration with a volumetric technique to determine water content in a wide range of samples, from 100 ppm to 100%. It's an effective tool for accurate water content analysis in various industries, including pharmaceuticals, food, chemicals, and more.
What kind of Karl Fischer titrations are EVA V1 and V3 based on?
The EVA V1 and V3 titrators are based on Volumetric Karl Fischer titration and use Amperometric indication.
What is the FFA™ KF control algorithm?
The FFA™ stands for Fast Forecasting Amperometric control algorithm, is used in the EVA V1 and V3 volumetric KF titrators from METTLER TOLEDO.
The FFA™ control relies on the measured signal of the dSens M143 digital polarized double platinum pin electrode, which detects the presence of water and calculates the amount of titrant to add to the system to compensate for it at a 10 Hz rate. The FFA™ also categorizes the chemical system in the KF cell based on the measured data, enabling it to automatically adjust control parameters to efficiently add the exact amount of titrant necessary to titrate all the water contained in a sample. Read more.
What are the advantages of the amperometric vs voltametric indication?
While both amperometry (UPol) and voltametry (IPol) can be utilized to measure a KF titration. Amperometric indication in Karl Fischer titration has the advantage of providing a linear relationship between iodine concentration and measured current, allowing for online forecasting of the necessary titrant volume and faster analysis times. In contrast, voltametric indication relies on a potential reading and can experience significant oscillations in slow iodine-water reaction situations, making it less sensitive around the endpoint of the titration.
What is the dead volume of the EVA burettes, and why is it beneficial to have a low dead volume?
A low dead volume is beneficial for burettes because it reduces the residual liquid in the burette after dispensing. The EVA titrator boasts an automatic burette emptying feature that replaces liquid with air. Dead volume, or the residual volume of liquid that cannot be displaced, poses a safety hazard during burette maintenance and cleaning. The EVA burettes have a very low dead volume of only 54 μL
Can the EVA KF titrator analyze samples that are not soluble in Karl Fischer solvent?
Yes, the EVA KF Titrators can analyze samples that are not soluble in Karl Fischer solvent. The EVA V1 titrator has several applicative approaches to bring the water of an insoluble sample into the KF solution, including elevated temperature (by the use of a thermostatable vessel), internal extraction (by the use of auxiliary solvents), and gas-phase extraction (DO308 oven). However, for challenging samples, the EVA V3 titrator is recommended as it offers additional features such as homogenizers that crush the sample and bring the water into solution, blank methods to adjust the result for water entry during homogenizing, and external extraction, allowing users to extract water from the sample using a solvent and measure aliquots from the resulting solution.
Does the EVA titrator support the internal extraction of solid samples using a homogenizer and if so, which homogenizer models are compatible?
Yes, the EVA V3 titrator supports the internal extraction of solid samples via homogenizer. The following homogenizer models are supported:
These homogenizers are automatically recognized when connected to the EVA titrator via USB A socket. The necessary USB cable is delivered along with the homogenizers. An adapter is also required to connect the homogenizer to the KF cell (material number 30869296 for Kinematica Polytron PT1300D and material number No 30869297 for IKA T25 Easy Clean digital).
Can the EVA titrators be connected to an InMotion KF autosampler?
Yes.
• EVA V1 and C1 work with the compact InMotion KF Six autosampler, which holds five sample positions, ideal for unattended low-volume batches.
• EVA V3 and C3 accept the larger InMotion KF Flex & Pro autosamplers, offering rack capacities from 19 to 25 samples depending on vial size, for true walk-away, high-throughput operation.
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