Hydrogenation and High Pressure Reaction Monitoring
Typically, hydrogenations encounter challenges with reaction kinetics, selectivity, reactivity and endpoint variability from batch to batch and scale-up. Real time in situ monitoring of these parameters allows for a better understanding of the process and therefore control – which is difficult to achieve with traditional offline techniques.
Four case studies from the pharmaceutical and high value chemical industries are presented:
- Nitrobenzyl Reduction
- Rosenmund Reduction
- Pyrazine Reduction
- Reductive Amination
Jennifer Andrews is a Ph.D. Chemist dedicated to the use of in situ FTIR for the development and safe scale-up of (bio)chemical processes. As a result, (bio)pharma and chemical companies bring products to market faster, at lower costs and with higher quality. Jennifer is currently a Senior Technology and Applications Consultant at METTLER TOLEDO.