Researchers working in chemical synthesis are under increasing pressure to discover and develop innovative pathways and robust chemical processes as quickly as possible. Inline Process Analytical Technologies (PAT) are capable of providing important clues that enable researchers to understanding the kinetics, pathway, and mechanisms of chemical reactions. Armed with increased reaction understanding, scientists are able to quickly optimize and scale up processes with increased robustness and performance. View the chemical synthesis applications library for recent publications and industry applications.
Researchers applied in situ reaction monitoring to understand the activity and robustness of new hydroformylation/hydrogenation catalyst components. By measuring kinetics, pathway and reaction mechanisms, optimal conditions for catalyst performance were identified.
Researchers in chemical synthesis often apply Design of Experiments (DoE) to maximum information when planning controlled experimentation. Product composition, stereo-specificity, yield, and impurities are optimized by changing reaction conditions such as temperature, solvent, catalyst, and concentrations of substrate or reagent. Efficient investigation of the influencing factors with only a small number of experiments requires experiments to be conducted under well-controlled, accurate and reproducible conditions. All of this preferably takes places automated or semi-automated at small scale and can quickly lead to optimized reaction conditions.
Small volume chemical synthesis workstations allow chemists to quickly and efficiently carry out experiments day and night with control over temperature, mixing, dosing and pH. Combining automated lab reactors with unattended, representative sampling or in situ analytical tools provides an additional level of process development understanding from particle size to the molecular level of reaction route, kinetics and reaction progression. These chemical synthesis workstations are easy-to-use, highly repeatable and interconnected through software control and data sharing.
To Synthesize Breakthrough Molecules
Discover how researchers apply effective methods to develop new synthetic pathways and optimize critical process conditions. 4 case studies highlight how leading pharmaceutical companies expand chemical synthesis lab performance.
Highly reactive chemistries have potentially hazardous reactants, intermediates and products and often involve highly exothermic reactions. Ensuring safe operating conditions, minimizing human exposure, and gaining the maximum amount of information from each experiment are key factors in successfully designing and scaling-up highly reactive chemistries. In situ reaction monitoring is critical since highly reactive materials are often unstable which limits offline sampling. Examples include chemical synthesis of Grignard reagents.
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