Accumulation of CO2 in fermentation and cell cultures can become a significant problem affecting productivity and product quality of recombinant proteins and monoclonal antibodies (mAbs). During this webinar, the following topics will be approached with a technical perspective:
- Measuring CO2 inline and monitor its accumulation
- Elevated CO2 partial pressure (pCO2) can alter protein glycosylation and affects the purity of mAbs.
- pCO2 is affecting media and intracellular osmolality
- Measuring pCO2 offline versus inline
- Monitoring and controlling CO2 during a fermentation
A list of scientific references for fermentation and cell culture processes will be also communicated and available after the webinar.
Thu Oct 24 2019 19:00 +0200 [ English ]
Your Online Event Presenter :
Olivier Berteau – Global Industry Manager, Pharmaceutical, METTLER TOLEDO
Olivier Berteau graduated from Institut du Genie Chimique, Toulouse France with a BS in Chemical Engineering. He has more than 25 years of hands-on operating experience within the biopharmaceutical industry with extensive upstream bioprocess expertise, process development, and analytical solutions. A unique combination of engineering and bioprocessing skills based upon experience for fermentation and cell culture processes at preclinical and clinical development phase. His experience also includes USP/DSP bioprocessing, perfusion, single-use technologies and several breakthrough-bioprocessing technologies. Along with his many years of biotech experience and a passion for innovation, his areas of focus are: cell culture and fermentation processes, design of equipment and instrumentation, cGMP environments, continuous manufacturing and process understanding/deviation.