Online Monitoring of MicroEncapsulation - 梅特勒-托利多

Online Monitoring of MicroEncapsulation

The effect that product and process variability has on microparticle is essential for successful development, optimization, and scale-up of an encapsulation process. A MicroEmulsion example from the US FDA is discussed during the presentation.
Benjamin Smith
7 Minutes

The main factors that affect the microencapsulation procedure and final microparticles are:

  • Matrix material level, composition, and inherent viscosity
  • Physiochemical properties of the active ingredient being entrapped
  • Matrix/active ingredient ration
  • Nature of the solvent employed
  • Level and properties of the stabilizer used
  • Shearing stress and the temperature of the emulsification

A MicroEmulsion example from the US Food and Drug Administration (FDA) is used during the presentation to show how to:
  • Understand the droplet system's response when changing process parameters.
  • Optimize the process by choosing conditions which ensure consistent endpoints, batch repeatability and process stability.
  • Scale-up the particle distribution while avoiding batch failure or inconsistency process performance and product quality.
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