Scale-Up of Anti-Solvent Addition Crystallizations | Webinar


Scale-Up of Anti-Solvent Addition Crystallizations

Optimization and Scale-up of Anti-solvent Addition Crystallizations from Lab to Pilot Plant

The webinar focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process. This protocol combines in situ Process Analytical Technologies (PAT) with Computational Fluid Dynamics (CFD) to facilitate the production of a knowledge based scale-up strategy for this mixing limited crystallization process.
Mark Barrett - APC (The Applied Process Company)
38 Minutes

Certain attributes of turbulent mixing have been identified to impact key crystallization characteristics, including:

Scale-Up of Anti-Solvent Addition Crystallizations
Guest Presenter Mark Barrett

This presentation focuses on the use of Process Analytical Technology (PAT) and Computational Fluid Dynamics (CFD) in understanding common industrial crystallization challenges and in turn facilitate the production of methods for the scale-up and scale-down of this process. A "scale-up toolbox" is used to optimize bench scale crystallizations to produce efficient, repeatable crystallizations.  Three case studies are included:

  • Case Study 1: Impact of Turbulent Mixing on Crystallization
  • Case Study 2: Overcoming Poor Anti-Solvent Addition Points
  • Case Study 3: Developing an Optimal Anti-Solvent Addition Profile

Guest Presenter

Mark Barrett received his Ph.D. in Chemical Engineering from University College Dublin (UCD).  His thesis work focused on crystallization development and scale-up.  Prior to co-founding APC in 2011, Mark worked for Solid State Pharmaceutical Cluster (SSPC) and Schering Plough.

Thank you for visiting We have tried to optimize your experience while on the site, but we noticed that you are using an older version of a web browser. We would like to let you know that some features on the site may not be available or may not work as nicely as they would on a newer browser version. If you would like to take full advantage of the site, please update your web browser to help improve your experience while browsing