连续流动化学 - 梅特勒-托利多

连续流动化学

提高安全性,缩短批次时间,提高质量和产率

采用PAT的流动化学
利用流动化学加快工艺开发
利用流动化学加快工艺开发
利用流动化学加快工艺开发
流动化学出版物
连续测量结构信息
自动化实验室反应釜

应用

连续流动化学应用

有机合成
筛选并优化催化作用、氢化、高分子合成及其他反应化学合成

工作在有机化学合成领域的化学家们,发现并开发了创新的化学反应和过程

Impurity Profiling of Chemical Reactions
Continuous Automated Reaction Sampling Improves Productivity and Understanding for Chemists

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

化学反应动力学研究
研究化学反应速率和在线测量动力学

原位化学反应动力学研究可实时提供反应组分的浓度依赖性,以确保更好地了解反应机理与途径。 由于数据具有全面性,因此在反应过程中采集到的连续数据可确保仅需较少几次实验即可计算出反应速率。 反应进程动力学分析 (RPKA) 在与合成相关的浓度条件下使用原位数据,并在整个实验过程中采集信息,以确保能够准确描述整个反应行为。

Crystallization and Precipitation
Optimize Crystal Size, Yield and Purity

Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development.

Heat Transfer and Process Scale-up
How Heat Transport in Agitated Vessels Affects Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Mass Transfer and Reaction Rate
Mixing in a Chemical Reactor and the Effect on Reaction Kinetics and Scale-up

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

有机合成

工作在有机化学合成领域的化学家们,发现并开发了创新的化学反应和过程

Impurity Profiling of Chemical Reactions

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

化学反应动力学研究

原位化学反应动力学研究可实时提供反应组分的浓度依赖性,以确保更好地了解反应机理与途径。 由于数据具有全面性,因此在反应过程中采集到的连续数据可确保仅需较少几次实验即可计算出反应速率。 反应进程动力学分析 (RPKA) 在与合成相关的浓度条件下使用原位数据,并在整个实验过程中采集信息,以确保能够准确描述整个反应行为。

Crystallization and Precipitation

Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development.

Heat Transfer and Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Mass Transfer and Reaction Rate

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

文档

关于连续流动化学的文献

点播网上技术交流讲座

连续流动化学
来自于 Snapdragon 的 Eric Fang 对连续流动化学在整条价值链的适用性进行了讨论。 在药物研发阶段及早地实施连续流动化学可产生最高价值。
加速工艺开发
注重连续工艺的工艺开发可采用传统间歇过程中使用的许多相同工具。 Nalas Engineering 通过合理的化学工程原理,借助原位与离线工具提供的数据开发连续工艺。 在本期网上技术交流讲座当中,将对如何通过采用工艺分析技术 (PAT) 的连续流动化学加速工艺开发进行讨论。
Using Data-Rich Experimentation to Enable the Development of Continuous Processes
David Ford of Nalas investigated an Oxidative Nitration reaction with a fast and highly exothermic oxidation step using reaction calorimetry and Proce...

白皮书

连续反应优化实验的快速分析
该白皮书 — 连续反应优化实验的快速分析 — 讨论了如何优化化学反应。
以更短的时间监测化学反应
“如何做到事半功倍?”这是化学研发实验室常见问题,研究人员需要从节省成本的角度快速提供化学品。我们的全新免费白皮书阐述了如何在更短的时间内获得优化的反应信息。

引文

ReactIR Citation List
Continuous measurements from infrared spectroscopy are widely used for obtaining reaction profiles, which are used to calculate reaction rates. This...

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连续流动化学技术

 
 
 
 
 
 
 
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