A chemical reaction is affected by multiple parameters, such as concentration, addition rate, temperature, the solvent, catalyst and pH. Further, reactions may also be affected by the stirrer type or speed which impact the mass transfer and further influence the result of the experiment. Rather than adopting a "trial-and-error" approach, where each parameter is examined individually and interactions between them cannot easily be detected, scientists apply the DoE methodology in the synthetic organic chemistry lab.
Case studies from the Zurich University of Applied Sciences (ZHAW) and Lonza SA apply the Design of Experiments (DoE) methodology to:
- Identify the Impact of Reaction Parameters
- Reduce Process Variability
- Shorten Chemical Development Cycles
- Support the Quality-by-Design (QbD) Approach