Eliminate Hold Time
In a multi-step batch process, it is important to move a synthesized intermediate compound to the next phase of the process and avoid hold times, which can be accompanied by decomposition. In the example presented in this video, the scientists needed to form an enantiomer-pure product from an enantiomer-pure reagent. The stereogenic center of the product is unstable and epimerizes. To achieve their goals, it was necessary to carefully control the reaction so that the levels of both the pure enantiomer product and the unwanted impurity were both achieved. In situ FTIR measurement of the conversion of starting material to product captured the end point of the reaction, and eliminated the hold time incurred from offline HPLC analysis. Product yield and purity targets were met and the time required for this process was reduced.