Using an automated synthesis reactor, center points conditions can be repeated in identical experiments to validate the reproducibility of the experiment setup, control over process parameter, and provide confirmation of consistent analytical measurements. By proving that the reaction is repeatable, at these conditions scientists gain confidence in the precise control of the synthesis reactor and in situ analytical measurements. Once process confidence is established, no additional or repeat experiments are necessary to confirm the central composite design of experiment (DoE) set of process parameters.
Inaccurate temperature or dosing control will produce inconsistent results requiring repetition of the experiment in order to find the correct response. Conventional synthesis tools, such as round bottom flasks, do not meet the rigorous requirements of design of experiment (DoE) studies as the control of temperature varies with reactant addition. Often they also cannot cope with the heat release (or consumption) during the chemical reaction or the reactant addition resulting in undefined conditions.