Bioburden and Total Organic Carbon (TOC) Analyzers - Overview - METTLER TOLEDO

    Bioburden and Total Organic Carbon (TOC) Analyzers

    Real-time microbial contamination and TOC analysis


    Monitor organic contamination with on-line TOC analysis

    Thornton total organic carbon sensors and analyzers provide fast, continuous measurement of ppb-level organic contamination. They utilize proven UV oxidation and conductivity measurement technology to effectively determine TOC concentrations.

    Our range of on-line TOC instruments

    • Meet pharmaceutical USP <643>, <645> and EP 2.2.44 requirements
    • Meet semiconductor ultrapure water monitoring requirements
    • Feature Intelligent Sensor Management diagnostics


    7000RMS Bioburden Analyzer
    5000TOCi Total Organic Carbon Analyzer
    450TOC Portable Total Organic Carbon Analyzer

    7000RMS Bioburden Analyzer

    5000TOCi Total Organic Carbon Analyzer

    450TOC Portable Total Organic Carbon Analyzer

    Laser-induced fluorescence (LIF) technology delivers instant detection and quantification of micro organisms and inert particles. Reduces lab measurements and increases product safety.
    Provides continuous, fast and reliable monitoring of TOC levels in various applications. With continuous on-line measurements, the 5000TOCi sensor ensures TOC excursions will not be missed.
    Employing proven continuous measurement technology, the 450TOC provides the fastest response available in a portable analyzer. Providing fast, convenient and affordable multi-point sampling capabiliti...
    High sensitivity
    One colony forming unit (CFU) limit detection.
    Easy to use
    No sample preparation, staining or reagents required. Touchscreen operation.
    Configurable to requirements
    User-defined alarm and alert thresholds.
    Low maintenance
    No moving parts. Automatic sanitizing function.
    Meets USP <643>, <645>, EP 2.2.44, ChP and JP16 requirements
    for the pharmaceutical industry
    Drastically reduces record keeping for release of water
    through simplified data collection with innovative Peak and Average measurements
    Improves the quality and reliability
    of calibration and System Suitability Testing (SST)
    Interfaces with the M800 multi-parameter analyzer/transmitter
    Reduce sampling time by 75%
    or more with on-the-spot results that eliminate lab analysis delays
    Dual USB ports allow simultaneous USB printer operation
    and data recording to a USB memory stick
    Fully compliant with USP<643>, EP2.2.44, Ch P
    and JP16 to meet pharmaceutical industry regulatory requirements
    1500RV Rinse Verification System
    4000TOC Total Organic Carbon Sensor
    TOC Pump Module

    1500RV Rinse Verification System

    4000TOC Total Organic Carbon Sensor

    TOC Pump Module

    The 1500RV Rinse Verification System is a fully integrated solution for verification of Total Organic Carbon and conductivity of Clean-In-Place final rinse water.
    Uses proven ultraviolet (UV) oxidation with differential conductivity to effectively determine TOC concentrations. Together with M300 single-channel transmitter offers a cost-effective solution.
    Provides a highly stable, metered flow of process water to the TOC sensor to ensure reliable and consistent TOC measurement performance.
    Reduce CIP Costs
    by immediately verifying completion of your final rinse with real-time measurements for TOC and conductivity, and reduce water and energy usage during the rinse process
    Maximize Production System Uptime
    with on-the-spot results showing the success of your rinse process, and immediately restore the production system to operation with minimal risk
    Quickly complete installation and startup
    with a fully integrated, turn-key solution combining TOC and conductivity measurement without complex engineering
    Provides a cost-effective solution for continuous TOC monitoring
    to meet requirements of major pharmacopeias
    Easy and economical integration into water purification make-up and distribution systems
    Designed for simple interface with single-channel M300 transmitter
    for process measurement in real time
    For applications where system pressure is too low to provide
    adequate flow through the TOC sensor
    For low-pressure applications where system pressure may vary routinely during operation
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