Safety by Design: A Real Time Monitoring of Calorimetry

In the chemical and pharmaceutical industry, most processes are carried out in batch or semi-batch mode. The hazard potential and risk of chemical processes are related to reactivity and toxicity of chemicals involved and the process design itself.

While the toxicity of the reagents cannot be influenced, the appropriate design of a process is essential to keep the reaction under control at any given time. As there is no steady-state in batch and semi-batch operation, the process dynamics becomes an important factor too and needs to be assessed carefully. Consequently, striving for an intrinsically safe process is thus the goal of process development.